How exercise rejuvenates cells, extending lifespan Above a cellular level, exercise can enhance muscle health &, ultimately

New research provides a window into how, Above a cellular level, exercise can enhance muscle health And, ultimately, exercise capacity, which is "the best predictor of mortality in the general population."

A new study published in the journal Nature Communications describes how exercise helps the whole body to keep the cells in the muscles healthy And strong.

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"Whether muscle is healthy or not really determines whether the entire body full is healthy or not," says lead researcher Prof. Zhen Yan, of the University of Virginia School of Medicine in Charlottesville.

"And exercise capacity, mainly determined By means of muscle size and function," he adds, "is the best predictor of mortality in the general population."

According to the new study, exercise improves muscle health by renewing its cellular powerhouse: the mitochondria. Mitochondria are crucial to the good functioning of our bodies, as well as to our overall health & longevity.

These little parts of the cell turn the food we eat into energy. Mitochondria  change proteins, fats, And sugars into the fuel that the body full Needs to live.

So, how does exercise affect the mitochondria in the muscles?

Exercise promotes mitophagy in mice

The answer given by the new study is through "mitophagy." Mitophagy describes the work By means of which damaged or defective mitochondria are selected & Removed, usually after a period of stress.

In the case of muscles, mitophagy contributes to keeping skeletal muscle healthy & strong. and to show how exercise induces mitophagy, Prof. Yan And team genetically modified mice to carry a gene that helps to put information Above the effects of physical activity.

This gene is called pMitoTimer. It makes mitochondria fluorescent, allowing the researchers to study mitophagy in vivo, after the mice engaged in 90 minutes of treadmill running.

Three to 12 hours after the running session, the researchers observed that mitochondria showed signs of stress. After 6 hours, they saw signs of mitophagy.

Prof. Yan explains the effect of exercise Above mitochondria through an analogy that one a vehicle inspection, the purpose of which is to remove defective cars from the streets.

Source: General online